Robotic-based in situ bioprinting

giovanni vozzi

Bioprinting has provided several advantages to traditional tissue engineering approaches for fabricating scaffolds for organ/tissue regeneration thanks to a precise and controlled biomaterials processing. Nevertheless, this technology, also known as in vitro bioprinting, suffers from several limitations when considering its clinical application, such as scaffold handling difficulty, risk of contamination, need of a maturation period in a bioreactor and shape/morphology of the bioprinted construct not perfectly matching with the defect site.

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3D printing of scaffolds and biomolecules for enhanced tissue repair

Tissue engineering typically uses a combination of biomaterial scaffolds, cells and signaling mechanisms (such as growth factors or mechanical stimuli) to restore the function of damaged or degenerated tissues. The research carried out in our laboratory investigates each of these three areas with target applications in tissues including bone, cartilage, skin, cardiovascular, respiratory, and neural tissues. 3D printing has allowed us to tune the mechanical properties of our scaffolds and to develop bioinks with enhanced regenerative potential.

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From Scaffold Design to Control Stem Cell Fate to Bioprinting

lorenzo moroni

Organs are complex systems, comprised of different tissues, proteins, and cells, which communicate to orchestrate a myriad of functions in our bodies. Technologies are needed to replicate these structures towards the development of new therapies for tissue and organ repair, as well as for in vitro 3D models to better understand the morphogenetic biological processes that drive organogenesis.

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