From cells to 3D tissues: Creating complex 3D tissue models using CELLINKs technologies

In this presentation, we will discuss how 3D bioprinting technologies enable the fabrication of more reliable tissue models, which have wide application, including the development and validation of the efficacy of pharmaceutical products, screening of drug therapies and understanding of tissue development and oncology processes.

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High-Resolution 3D Printing by Multiphoton Lithography

Multiphoton lithography (MPL) is set of methods offering a possibility of 3D structuring of a variety of materials at a high spatial resolution, unmatched by other additive manufacturing approaches. MPL relies on the nonlinear absorption of femtosecond laser pulses to induce photochemical processes, not necessarily limited to photopolymerization alone. An increasing portfolio of available materials enables utilization of the versatile capabilities of Multiphoton lithography, from producing complex volumetric 3D structures by means of cross-linking, to creating void patters within hydrogels already containing living cells.

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Creating centimeter-scale complex tissue geometries within seconds via Volumetric Bioprinting

Our finite ability to spontaneously regenerate our organs, associated with increasing longevity, reinforces the need for engineered human tissues. Bioprinting made constructing architecturally complex, centimeter-scale 3D living structures possible in hours, arranging cells and materials into pattern that can hasten maturation into functional tissues. Nevertheless, biological elements such as cells and biomolecules are sensitive to physical stimuli and have shortened lifetime in solution. This can result in the reduction of cell function proportionally to printing time.

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The emergence of 4D Bioprinting: Next Generation in regenerative medicine & human-machine interfacing

Stephen Gray

An overview of the 4D bioprinting industry and its potential impact on regenerative medicine and human-machine interfaces to diagnose, monitor and treat a wide range of diseases. Novel emerging biofabrication technologies and biomaterials with superior advantages such as nanoscale resolution & cells reaching high viability whilst maintaining metabolic and pluripotent characteristics.

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New Business Models in Healthcare: Point-of-care 3D Printing of Surgical Implants

deynys gurak

At its current stage of development A.D.A.M. focuses on orthopedic implants and have developed two proprietary material combinations and corresponding printers. In future, we are planning to modify the extrusion printing technology to be able to print other tissues and essentially move to 4D printing.

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Robotic-based in situ bioprinting

giovanni vozzi

Bioprinting has provided several advantages to traditional tissue engineering approaches for fabricating scaffolds for organ/tissue regeneration thanks to a precise and controlled biomaterials processing. Nevertheless, this technology, also known as in vitro bioprinting, suffers from several limitations when considering its clinical application, such as scaffold handling difficulty, risk of contamination, need of a maturation period in a bioreactor and shape/morphology of the bioprinted construct not perfectly matching with the defect site.

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Biofabrication and 3D Printing for Precision Healthcare

yan yan shery huang

The merging of biological matter with engineering components, could transform a number of emerging fields, including regenerative medicine and bio-machine interfaces. This presentation considers my group’s recent work in biofabrication and bioprinting techniques across different length scales. Particular focus is placed on the fabrication of extracellular matrix fibre analogue, embedded 3D printing, and guided tissue assembly that could extend the feature resolution and material functionality of tissue constructs.

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Development, characterization and encapsulation of drug loaded microgels in bioinks aimed at dentoalveolar bioprinting

Efficient delivery of growth factors and signaling molecules has an important impact on the outcome of tissue engineering strategies. However, maintaining the optimum concentration of such molecules is a challenge due to the short biological half-life on one hand, and the possibility of uncontrolled differentiation, inflammation and carcinogenicity on the other hand. While bioprinting has led to significant hope in regeneration strategies aimed at dentoalveolar region, inherent complexity and heterogeneity of these tissues highlights the demand for controlled delivery of targeted signaling molecules.

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